My Work — Mark Latham

What I'm working on

GCTB is rare enough that the research community is small and global collaboration is essential. I operate at the frontier of GCTB research, synthesising the latest findings and working toward actionable change.

Tumour biology

Building a comprehensive profile of what makes up a giant cell tumour of bone: understanding the cellular composition, molecular drivers, and targetable mechanisms to identify new avenues for treatment.

Novel treatment pathways

Looking beyond the current standard of care (surgery and denosumab) to identify viable therapeutic options. Areas of interest include B7-H3 targeted antibody-drug conjugates and precision medicine approaches.

Denosumab tapering

Contributing real-world patient data on extended dosing intervals. Helping build the evidence base for safe de-escalation strategies, an area with very limited published data.

Pilot research program

Working toward designing and initiating a research program to test novel treatment approaches for GCTB, with the goal of institutional backing and clinical viability.

Latest GCTB literature

I track all published GCTB research from PubMed, updated monthly. Browse the full curated feed of recent publications.

Browse GCT Literature

Partnerships

I work with a network of institutions, organisations, and clinicians who share the goal of improving outcomes for rare disease patients.

Rare Voices Australia

National peak body for rare diseases. Active partnership with regular research sharebacks and community engagement.

Rare Diseases NSW

State-level rare disease organisation. Collaborating on awareness, advocacy, and knowledge translation.

Precision Care Initiative

Consumer advisor on precision care medicine research, helping ensure patient perspectives shape the direction of personalised medicine.

Omico

Participant in the Cancer Screening Program (CaSP), contributing to genomic profiling research and molecular oncology for rare tumours.

Victorian Bone and Joint Specialists

Where my limb salvage surgery was performed. Ongoing clinical relationship with the orthopaedic oncology team.

Medical Oncology Victoria

Working alongside oncologists to stay at the forefront of GCTB treatment and manage ongoing denosumab therapy.

GCT Support

Global patient support group connecting people affected by giant cell tumours. Partnering on awareness, peer support, and knowledge sharing.

Speaking

I share my research and patient journey at events to raise awareness and connect with collaborators. If you think I'd be a good fit for an upcoming event, conference, or panel, get in touch. I'm available for guest speaking engagements on rare disease advocacy, patient navigation, and the GCTB treatment landscape.

Upcoming

Rare Disease Day 2026

"The Decisions That Define Us: A GCTB Patient's Journey", a 15-minute presentation at the Randwick Health Translation Hub (UNSW) for Rare Disease Day, 28 February 2026. Hosted by Rare Diseases NSW and the Precision Care Initiative. Sharing the patient perspective on navigating rare disease treatment decisions with an audience of clinicians, researchers, patients, and consumers.